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目的:观察果糖和纳洛酮联合治疗急性酒精中毒的疗效;方法:对5％果糖注射液和纳洛酮注射液进行配伍稳定性考察,确定可配伍使用;采用前瞻性单盲随机对照研究,将110例患者随机分为两组:56例急性酒精中毒患者(试验组)用果糖和纳洛酮联合治疗,54例急性酒精中毒患者(对照组)单用纳洛酮治疗。结果:试验组和对照组临床观察指标有统计学差异 (P<0．01);结论:5％果糖注射液和纳洛酮注射液对治疗急性酒精中毒有协同作用,值得在临床抢救中推广使用。
OBJECTIVE: To observe the efficacy of fructose and naloxone in the treatment of acute alcoholism. Methods: The stability of 5% fructose injection and naloxone injection were investigated and confirmed to be compatible. A prospective single-blind randomized controlled study was conducted, 110 patients were randomly divided into two groups: 56 patients with acute alcoholism (experimental group) with fructose and naloxone combined treatment, 54 patients with acute alcoholism (control group) alone naloxone treatment. Results: There were significant differences between the experimental group and the control group (P <0.01). Conclusion: 5% fructose injection and naloxone injection have synergistic effect on the treatment of acute alcoholism and should be promoted in clinical rescue use.