某些药物能影响味觉,其中多数药物可引起味觉减退。然而有些药物则能增加对酸、甜、苦味的敏感性,少数药物可引起金属味和其它异常味觉。药物引起的味觉功能紊乱还可能与所治疗的疾病性质有关。例如络合剂青霉胺治疗风湿性关节炎时,约25～33％的患者引起味觉减退;而对患有Wilson氏病(体内高铜症)的病人其发生率仅占4％。药物引起的味觉障碍持续时间有明显差异性。灰黄霉素持续全身给药时,味觉损害更为严重,停药后仍可持续数月。相反,青霉胺或巯甲丙脯酸引 Some drugs can affect taste, most of which can cause taste loss. However, some drugs can increase the sensitivity to sour, sweet and bitter taste. A few drugs can cause metallic taste and other abnormal taste. Drug-induced disorders in taste may also be related to the nature of the disease being treated. For example, when the complexing agent penicillamine is used to treat rheumatoid arthritis, about 25 to 33% of the patients cause taste loss, whereas the incidence of Wilson’s disease (high copper disease in vivo) accounts for only 4%. Drug-induced taste disorders have significant differences in the duration. Griseofulvin sustained systemic administration, more serious taste damage, after stopping can continue for several months. In contrast, penicillamine or captopril lead