有人认为免疫反应的缺乏和低下与儿童细菌性脑膜炎的发病机制有关。1977年Hobbs等人报告缺少IgM易导致暴发性脑膜炎球菌感染。作者在1969～1973年期间对治疗过的59例细菌性脑膜炎患儿进行了检查,其中27例流感嗜血杆菌脑膜炎,23例脑膜炎球菌脑膜炎和9例肺炎双球菌脑膜炎。每例患者连续取3～5份血标本。第1份在入院当天,其他在2～3天,5～6天,11～12天和15～18天。每份血清标本均 Some people think that the lack of immune response and low bacterial meningitis and the pathogenesis of children. In 1977, Hobbs et al. Reported that lack of IgM predisposes to fulminant meningococcal infection. The authors examined 59 treated children with bacterial meningitis from 1969 to 1973, 27 of whom were Haemophilus influenzae meningitis, 23 of meningococcal meningitis and 9 of pneumococcal meningitis. Take 3 to 5 blood samples continuously for each patient. The first day on admission, the other in 2 to 3 days, 5 to 6 days, 11 to 12 days and 15 to 18 days. Each serum sample are