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幽门螺杆菌(HP)感染与消化性溃疡的发生与复发有密切关系,本文对78例消化性溃疡患者采用克菌胶囊治疗,疗效显著。现报告如下。 临床资料:选择2001年4月至2002年4月收治患者78例,男42例,女36例;年龄21～67岁。均经胃镜检查确诊有活动性溃疡,局部粘膜活检进行尿素酶快速试验为阳性,证实有Hp感染。将患者随机分成两组各39例,两组年龄、性别、胃溃疡和十二指肠溃疡所占比例无显著性差异(P>0.05)。 治疗方法:治疗组服用克菌胶囊0.375g/次,每日3次,餐前半小时服用;对照组服用羟氨苄青霉素0.25g/次、黄连素0.3g/次、庆大霉素8万U/次,均为每日3次,餐前半小时服用。另外,两组患者均给予吗丁啉、法莫替丁等药物,总疗程均为1个月。疗程结束后于半年和1年后复查胃镜,观察溃疡愈合情况,检测HP是否转阴。溃疡愈合标准为胃镜下溃疡消失或疤痕形成;HP清除标准为胃镜下取局部粘膜进行尿素酶快速试验,阴性者为HP已清除。
Helicobacter pylori (HP) infection and the occurrence and recurrence of peptic ulcer are closely related to the 78 cases of peptic ulcer patients treated with bacteria capsule, a significant effect. The report is as follows. Clinical data: Select April 2001 to April 2002 78 patients admitted to the hospital, 42 males and 36 females; aged 21 to 67 years. Are confirmed by gastroscopy with active ulcers, local mucosal biopsy urease rapid test was positive, confirmed Hp infection. The patients were randomly divided into two groups of 39 cases. There was no significant difference in age, gender, gastric ulcer and duodenal ulcer between the two groups (P> 0.05). Treatment: The treatment group taking Capillary capsule 0.375g / times, 3 times a day, taking half an hour before meals; control group taking amoxicillin 0.25g / times, berberine 0.3g / times, gentamicin 80,000 U / Times, are 3 times a day, taking half an hour before meals. In addition, both groups were given domperidone, famotidine and other drugs, the total course of treatment were 1 month. After the end of treatment in six months and 1 year after the review of gastroscopy to observe the healing of ulcers to detect HP is negative. Ulcer healing criteria for the disappearance of gastric ulcer or scar formation; HP removal criteria for local mucosal endoscopy underwent urease rapid test, the negative was HP has been cleared.