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【目的】为了证明疣状柳珊瑚(Verrucella umbraculum)中的主要化学成分是八放二萜类化合物,并获得结构新颖的八放二萜类化合物。【方法】采用硅胶柱色谱、Sephadex LH-20和反相半制备HPLC等方法分离化合物,根据波谱数据以及文献对照方法,确定其结构。【结果】从疣状柳珊瑚分离得到10个八放二萜类化合物,鉴定为junceellin A(1)、renillafoulin A(2)、praelolide(3)、(-)-11α,20α?epoxy-4-deacetyljunceellolide(4)、umbraculolide A(5)、umbraculolide C(6)、junceellolide A(7)、13-deacetylnui-inoalide A(8)、erythrolide T(9)、erythrolide U(10)。【结论】化合物3~10为首次从疣状柳珊瑚中分离得到,丰富了该属柳珊瑚中的化学成分类型。
【Objective】 In order to prove that the main chemical component of verrucella umbraculum is octapeptide diterpene, and the novel structure of octapeptide diterpenoid is obtained. 【Method】 The compounds were isolated by silica gel column chromatography, Sephadex LH-20 and reversed-phase semi-preparative HPLC. The structures of the compounds were determined by spectral data and literature comparison. 【Result】 Ten eight-place diterpene compounds isolated from the warty genus Coralia were identified as junceellin A (1), renillafoulin A (2), praelolide (3), (-) - 11α, deacetyljunceellolide (4), umbraculolide A (5), umbraculolide C (6), junceellolide A (7), 13-deacetylnui-inoalide A (8), erythrolide T (9), erythrolide U (10). 【Conclusion】 Compounds 3 ~ 10 were isolated from warty corals for the first time, which enriched the chemical constituents in this genus.