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目的:探讨c-myc癌基因在子宫内膜癌中的表达及临床意义。方法:采用免疫组化ABC法检测49例子宫内膜癌中c-myc癌基因蛋白的表达,与对照组临床病理学特征及预后相比较,进行统计分析。结果:表明25例正常和增生过长的子宫内膜c-myc表达阴性,49例子宫内膜癌中10例c-myc表达阳性,占20%。c-myc的表达与组织学分级、手术分期及生存率显著相关,但与肌层浸润深度无关。结论:c-myc癌基因蛋白可能在子宫内膜癌的发生、发展中起作用,并可能提示患者的预后。
Objective: To investigate the expression of c-myc oncogene in endometrial carcinoma and its clinical significance. Methods: The expression of c-myc oncoprotein in 49 cases of endometrial carcinoma was detected by immunohistochemical ABC method, and compared with the control group’s clinicopathological characteristics and prognosis. Statistical analysis was made. Results: 25 cases of normal and hyperproliferative endometrial c-myc negative expression, 49 cases of endometrial cancer in 10 cases of c-myc positive expression, accounting for 20%. The expression of c-myc was significantly associated with histological grade, surgical stage and survival rate, but not with depth of myometrial invasion. Conclusion: The c-myc oncogene protein may play an important role in the carcinogenesis and progression of endometrial carcinoma and may indicate the prognosis of patients.