【摘 要】
：
采用阻断沙土鼠双侧颈总动脉60min,继之再灌流120min的实验模型,检测了皮层脑电图(EEG),大脑皮层水、电解质、前列腺素及超微结构等变化。结果表明,脑缺血再灌流后EEG严重抑
【机 构】
：
青岛医学院病理生理学教研室,昆明医学院,昆明医学院
论文部分内容阅读
采用阻断沙土鼠双侧颈总动脉60min,继之再灌流120min的实验模型,检测了皮层脑电图(EEG),大脑皮层水、电解质、前列腺素及超微结构等变化。结果表明,脑缺血再灌流后EEG严重抑制;脑组织水、钠、钙含量增加;血栓素(TXB_2)增加;前列环素(6-Keto-PGF_(1α))减少;缺血神经元的超微结构损伤进一步加重。提示沙土鼠脑缺血再灌流后脑组织损伤加重。对上述变化发生的可能机制进行了讨论。
The cortical electroencephalogram (EEG), cerebral cortex water, electrolytes, prostaglandins, and ultrastructure were detected by blocking the common carotid arteries of both sides for 60 min and then reperfusion for 120 min. The results showed that EEG was severely inhibited after cerebral ischemia and reperfusion; brain water, sodium and calcium contents increased; thromboxane (TXB_2) increased; prostacyclin (6-Keto-PGF_(1α)) decreased; ischemia neurons Ultrastructural damage is further aggravated. It indicated that the damage of brain tissue was worse after cerebral ischemia and reperfusion in gerbils. The possible mechanisms for the above changes have been discussed.
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