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前言日本学者杉浦信之(1983)首创超声导向经皮经肝瘤内注射酒精(PAI)治疗小肝癌。随后,有少数日本学者将此疗法用于小肝癌手术切除之前,目的在于防止手术切除后局部发生残癌。现代影像技术特别是实时超声及血清αFP测定的敏感性提高能发现许多小肝癌,要处理这些病人,特别是拒绝手术的病人,国外学者一致认为超声导向瘤内注入酒精的方法是有效的。近年应用PAl治疗肝癌的文献渐趋增多,且适应征逐渐扩大,已引起临床医师的极大兴趣。
Foreword Japanese scholar Sugiura Nobuyuki (1983) first ultrasound-guided percutaneous intrahepatic injection of alcohol (PAI) in the treatment of small hepatocellular carcinoma. Subsequently, a small number of Japanese scholars applied this therapy to surgical resection of small hepatocellular carcinoma to prevent residual cancer locally after surgical resection. The sensitivity of modern imaging techniques, especially real-time ultrasound and serum alpha-FP assays, has led to the discovery of many small liver cancers. To deal with these patients, especially those who refuse surgery, foreign scholars agree that ultrasound-guided infusion of alcohol into the tumor is effective. In recent years, the application of PAl in the treatment of liver cancer has gradually increased, and the indications have gradually expanded, which has caused great interest among clinicians.