肿瘤细胞组织上常有一些生长抑素受体的过度表达,生长抑素类似物与生长抑素受体能够高特异性地结合。因此,用18F标记的生长抑素类似物作为肿瘤示踪剂可对生长抑素受体阳性肿瘤进行诊断。为开发一种18F标记的生长抑素类似物,本文用Al18F复合物和生长抑素类似物Lys(NOTA)-TOCA通过螯合反应快速高效地制备了Lys([Al18F]NOTA)-TOCA,放化合成时间为25~30 min,标 Some tumor cells often have somatostatin receptor overexpression, somatostatin analogs and somatostatin receptors can be highly specific binding. Therefore, somatostatin receptor positive tumors can be diagnosed with 18F labeled somatostatin analogues as tumor trackers. In order to develop an 18F-labeled somatostatin analogue, Lys ([Al18F] NOTA) -TOCA was prepared rapidly and efficiently by the chelation reaction with Al18F complex and somatostatin analogue Lys (NOTA) -TOCA The synthesis time is 25 ~ 30 min, standard