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慢性阻塞性肺疾病(COPD)是一种常见病、多发病,表现为不完全可逆的气流受限。肺动脉高压(PAH)是一组少见的、预后不良的疾病,以增高的肺动脉压力和阻力为特征。慢性缺氧及慢性炎症是COPD相关性PAH的主要发病原因。目前已证实Rho/Rho激酶通路参与PAH的病理生理过程,在PAH的动物模型中阻断该信号通路能够改善疾病的病理改变与预后。
Chronic obstructive pulmonary disease (COPD) is a common and frequently-occurring disease characterized by limited airflow that is not completely reversible. Pulmonary hypertension (PAH) is a rare, poor prognosis of disease characterized by increased pulmonary artery pressure and resistance. Chronic hypoxia and chronic inflammation are the main causes of COPD-related PAH. It has been confirmed that the Rho / Rho kinase pathway is involved in the pathophysiological process of PAH. Blocking this signaling pathway in an animal model of PAH can improve the pathological changes and prognosis of the disease.