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背景:临床上常以流式细胞检测受者外周血CD4、CD8细胞比值来揭示与排斥或感染相关的关系。目的:探讨肾移植后排斥或感染时外周血CD4+及CD8+T细胞(简称CD4和CD8细胞)亚群计数的变化和意义。方法:应用流式细胞仪检测肾移植121例受者CD4、CD8细胞数进行检测。根据入院病情将患者分为移植后正常组、急性排斥组、肺部感染组进行观察。结果与结论:移植后正常患者和急性排斥患者相比,CD4、CD8细胞数差异均无显著性意义(P>0.05)。肾移植后肺部感染患者CD4、CD8细胞数则均显著低于移植后正常组(P<0.001)。当感染控制、症状改善时,CD4、CD8细胞数显著升高(P<0.001)。说明肾移植后CD4和CD8细胞计数可以作为免疫状态的参考,其对于感染的参考价值大于排斥,动态观察分析有助于指导治疗。
BACKGROUND: Clinically, the ratio of CD4 and CD8 cells in peripheral blood of recipients is often detected by flow cytometry to reveal the relationship with rejection or infection. Objective: To investigate the changes and significance of CD4 + and CD8 + T cell subsets (CD4 and CD8) subsets in peripheral blood after rejection or infection after renal transplantation. Methods: Flow cytometry was used to detect the number of CD4 and CD8 cells in 121 recipients of kidney transplantation. The patients were divided into normal group, acute rejection group and pulmonary infection group according to the admission condition. RESULTS AND CONCLUSION: Compared with patients with acute rejection, there was no significant difference in the number of CD4 and CD8 cells between normal and posttransplantation patients (P> 0.05). The number of CD4 and CD8 cells in patients with lung infection after kidney transplantation were significantly lower than those in normal group after transplantation (P <0.001). When infection was controlled and the symptoms improved, the number of CD4 and CD8 cells was significantly increased (P <0.001). It shows that the count of CD4 and CD8 after renal transplantation can be used as a reference for immune status, which is more valuable than infection for the reference of infection. Dynamic observation and analysis can help to guide the treatment.