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目的 在大鼠腹主动脉移植硬化模型上，探讨Ｓ１０８、丹参对抗移植动脉硬化的作用。方法 大鼠３５ 只随机分为：Ａ组为非移植ＳＤ组，Ｂ组为同品系移植缺血＜ ３０ ｍｉｎ 组，Ｃ 组为异品系移植缺血＜ ３０ ｍｉｎ 对照组，Ｄ组为异品系移植缺血＜３０ ｍｉｎ Ｓ１０８ 加丹参处理组，术后６０ ｄ 切取植入的腹主动脉行光镜、电镜检查，并采用ＭＩＡＳ－ ３００ 计算机图象分析系统，自动测量移植腹主动脉管腔面积、内膜面积及中膜面积。结果 Ｂ组和Ａ组比较，术后６０ ｄ 时动脉内膜未见明显增厚（Ｐ＞０－０５） ，Ｃ组内膜明显增厚（ 与Ａ组、Ｂ组比较，Ｐ＜ ０－０５） 。Ｄ组与Ｃ组比较，内膜增厚有所减轻（Ｐ＜０－０５）。病理观察表明，Ｃ 组、Ｄ 组增生的内膜均由单核／ 巨噬细胞与平滑肌细胞构成。Ｃ组动脉有较严重的细胞浸润，中膜平滑肌细胞坏死，弹力纤维膜断裂。Ｄ 组动脉病理改变明显减轻。结论 Ｓ１０８ 加丹参可以延长异品系大鼠腹主动脉移植硬化的进展。
Objective To investigate the effect of S108 and Salvia miltiorrhiza on arteriosclerosis graft in rat model of abdominal aortic graft and sclerosis. Methods Forty-five rats were randomly divided into the following groups: group A was non-transplanted SD group, group B was the same strain transplanted with ischemia <30 min group, group C was the non-transplanted group with ischemia <30 min control group, group D was the transplantation of different strains In the S108 and Salvia group treated with ischemia for 30 min, the abdominal aorta was harvested at 60 days after operation and examined by light and electron microscopy. The MIAS-300 computer image analysis system was used to automatically measure the lumen area of the transplanted abdominal aorta. Intimal area and media area. Results Compared with group A, there was no obvious thickening of the arterial intima at 60 days after operation (P>0-05), and the intima of group C was significantly thickened (comparison with group A and group B, P<0-05). ). Compared with group C, the thickness of intima was decreased in group D (P<0-05). Pathological observations showed that the proliferating intima of both groups C and D consisted of monocytes/macrophages and smooth muscle cells. The arteries in group C had severe cell infiltration, necrotic smooth muscle cells and ruptured elastic fiber membranes. Arterial pathological changes in group D were significantly reduced. Conclusion S108 plus Salvia miltiorrhiza can prolong the progression of abdominal aortic allograft hardening in rats of different strains.