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目的了解流行性感冒(流感)病毒流行后婴幼儿获得新近感染的情况。方法选择出生后3～4月龄、10～11月龄时两次暴露于流感病毒甲1(H1N1)亚型流行高峰的13月龄幼儿,和出生后5～6月龄时暴露于H1N1亚型流行高峰的8月龄婴儿的血清,测定流感病毒抗体。结果两次暴露于流感病毒H1N1亚型流行高峰的13月龄组中,H1N1亚型流感病毒的抗体阳性率为31.47%;暴露1次H1N1亚型流行高峰的8月龄组,抗体阳性率为26.42%;差异无统计学意义(χ2=1.207,P>0.05)。结论13月龄组的幼儿可能在≤4月龄的那次H1N1亚型的暴露中,由于胎传抗体的保护而很少被感染,而8月龄组的婴儿是≥5月龄时才暴露,比13月龄组≤4月龄时的那次暴露更易被流感病毒感染。
Objective To understand the recent infection of infants and young children after the influenza (influenza) virus has been circulating. Methods Three to four months of age at birth and 13 months of age at 10 to 11 months of age were exposed twice to the peak of H1N1 influenza type and exposed to H1N1 subtype at 5 to 6 months of age Type of epidemic peak of 8-month-old infant serum, the determination of influenza virus antibodies. Results The positive rate of the H1N1 subtype influenza virus in the 13-month-old group twice exposed to the peak of the H1N1 influenza virus was 31.47%. The positive rate of the antibody in the 8-month-old group who had the highest prevalence of the H1N1 subtype was 26.42%; the difference was not statistically significant (χ2 = 1.207, P> 0.05). Conclusion Toddlers in the 13-month-old group may be infrequently infected due to the protection of the fetal antibodies in that H1N1 subtype ≤ 4 months of age, whereas infants in the 8-month-old group are exposed at ≥ 5 months of age , Was more susceptible to influenza virus infection than the exposure at 13 months of age ≤ 4 months of age.