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近二十年来,在体内发现了一些特殊的环状核苷酸,研究得较多的是3’,5’-环腺苷酸(cAMP)和3’,5’-环鸟苷酸(cGMP),虽含量极少,但具有极重要的生理功能,与人类疾病有着密切的关系. 一、简史五十年代初,在圣路易斯,一些化学家在检查ATP的碱性水解中发现,有一种核苷酸极易从许多产物中辨别出来.同时,在克利夫兰,另一些生化学家也在研究激素诱导糖原分解中观察到,ATP磷酸转移能活化相对不活动的物质.1957年,Sutherland等用激素保温肝
In the recent two decades, some special cyclic nucleotides have been found in the body, and 3 ’, 5’-cyclic adenosine monophosphate (cAMP) and 3’, 5’-cyclic guanosine monophosphate (cGMP ), Although the content is minimal, but has extremely important physiological functions, and has a close relationship with human disease.A brief history In the early fifties, in St. Louis, some chemists in the examination of ATP alkaline hydrolysis found that there is a Nucleotides can easily be discerned from many products, while in Cleveland other biochemists have also observed in hormone-induced glycogenolysis that ATP phosphorylation can activate relatively inactive substances. In 1957 Sutherland et al Liver with hormones