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本文采用切口末端标记方法前瞻性观察了16例正常胃牯膜标本和31例幽门螺杆菌阳性胃炎患者抗幽门螺杆菌治疗前后胃窦部上皮细胞凋亡的变化。结果表明,幽门螺杆菌感染者的凋亡指数(0.7044)明显高于正常对照者(P<0.005);幽门螺杆菌根除后凋亡指数由0.7624降至0.1159(P<0.005),而持续阳性者则无明显降低;凋亡指数与胃炎程度无关。提示幽门螺杆菌能促进胃上皮细胞凋亡,这可能是幽门螺杆菌引起胃癌和溃疡的重要机理。
In this paper, the incision end marking method prospectively observed in 16 cases of normal gastric membrane specimens and 31 cases of Helicobacter pylori-positive gastritis in patients with Helicobacter pylori infection before and after treatment of gastric antral epithelial cell apoptosis changes. The results showed that the apoptosis index of Helicobacter pylori infection group (0.7044) was significantly higher than that of the control group (P <0.005), and the apoptosis index of H. pylori eradication decreased from 0.7624 to 0.1159 (P <0.005) No significant reduction; apoptosis index has nothing to do with the degree of gastritis. Suggesting that Helicobacter pylori can promote gastric epithelial cell apoptosis, which may be caused by Helicobacter pylori gastric cancer and ulcers an important mechanism.