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目的:观察埃索美拉唑对十二指肠球溃疡合并幽门螺杆菌感染的治疗效果,为临床实践以及今后科研发展奠定发展基础。方法:选取消化内科78例幽门螺杆菌呈阳性的十二指肠球溃疡患者为研究对象,采用数字随机法分为治疗组(n=39)和对照组(n=39)。治疗组口服埃索美拉唑、利复星、克拉霉素,给予对照组口服法莫替丁、利复星、克拉霉素,观察并对比两组患者溃疡愈合率、HP清除率和临床症状的改善情况。结果:治疗组和对照组镜下溃疡愈合率分别为39例(100%)和31例(79.48%),对比差异有统计学意义(P<0.05)。结论:埃索美拉唑能有效缓解临床症状,促进溃疡愈合,与抗生素联合应用可有效提高HP清除率。采用埃索美拉唑治疗法对于临床十二指肠球溃疡合并幽门螺杆菌感染具有前瞻和借鉴意义,有利于推动推进疾病的诊断与治疗。
Objective: To observe the effect of esomeprazole on the treatment of duodenal ulcer with Helicobacter pylori infection, and lay the foundation for the development of clinical practice and future scientific research. Methods: A total of 78 patients with H. pylori-positive duodenal ulcer were selected from the Department of Gastroenterology. The patients were randomly divided into treatment group (n = 39) and control group (n = 39). In the treatment group, oral esomeprazole, rifampicin and clarithromycin were given orally, and famotidine, rifampicin and clarithromycin were given orally to the control group. The healing rate, HP clearance rate and clinical symptoms of the two groups were observed and compared Improve the situation. Results: The healing rates of ulcer in the treatment group and the control group were 39 cases (100%) and 31 cases (79.48%) respectively, the difference was statistically significant (P <0.05). Conclusion: Esomeprazole can effectively relieve clinical symptoms and promote the healing of ulcer. Combined with antibiotics can effectively improve the clearance rate of HP. The use of esomeprazole treatment for clinical duodenal ulcer with Helicobacter pylori infection has a prospective and referential significance, will help promote the diagnosis and treatment of diseases.