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目的探讨口服康复新液联合兰索拉唑片治疗糜烂性胃炎患者临床疗效及对患者血清肿瘤坏死因子-α、白介素-6、C反应蛋白水平的影响。方法选自2014年3月—2015年9月杭州市第一人民医院收住的糜烂性胃炎患者107例,按照随机数字表法随机分为治疗组54例与对照组53例。对照组给予兰索拉唑片治疗,治疗组在对照组基础上结合口服康复新液治疗。两组治疗疗程均为4周。比较两组患者治疗疗效,治疗前后胃镜积分和炎症因子指标水平变化,及用药期间不良反应发生情况。结果治疗组总有效率(88.89%)高于对照组(71.70%,P<0.05);两组治疗后胃镜积分明显降低(P<0.05);治疗组治疗后胃镜积分低于对照组(P<0.05);两组治疗后血清肿瘤坏死因子-α、白介素-6、C反应蛋白水平明显下降(P<0.05);治疗组治疗后血清肿瘤坏死因子-α、白介素-6、C反应蛋白水平低于对照组(P<0.05);两组均未见严重不良反应。结论口服康复新液联合兰索拉唑片治疗糜烂性胃炎患者疗效显著,可降低血清肿瘤坏死因子-α、白介素-6、C反应蛋白水平,且安全可靠。
Objective To investigate the clinical efficacy of Oral Rehabilitation Combined with Lansoprazole Tablet in the treatment of patients with erosive gastritis and its effect on serum levels of tumor necrosis factor-α, interleukin-6 and C-reactive protein. Methods From March 2014 to September 2015, 107 cases of patients with erosive gastritis admitted to Hangzhou First People’s Hospital were randomly divided into treatment group (n = 54) and control group (n = 53) according to random number table. The control group was treated with lansoprazole tablets, and the treatment group was treated with new oral solution based on the control group. The two groups were treated for 4 weeks. The curative effect of the two groups were compared, the changes of gastroscope score and index of inflammatory cytokines before and after treatment, and the occurrence of adverse reactions during the treatment. Results The total effective rate (88.89%) in the treatment group was significantly higher than that in the control group (71.70%, P <0.05). Gastroscopy score was significantly lower in both groups after treatment (P <0.05) 0.05). The levels of serum tumor necrosis factor-α, interleukin-6 and C-reactive protein were significantly decreased in both groups after treatment (P <0.05). The levels of serum tumor necrosis factor-α, interleukin-6 and C-reactive protein In the control group (P <0.05); no serious adverse reaction was found in both groups. Conclusion Oral rehabilitation combined with lansoprazole tablets treatment of patients with erosive gastritis significant effect, can reduce serum levels of tumor necrosis factor-α, interleukin -6, C reactive protein, and safe and reliable.