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从323例确诊为日本脑炎的病人中,发现16个病人的神经系统中有日本脑炎病毒(JEV)持续存在的免疫学和病毒学证据。9/16病人的脑脊液(CSF)中,症状出现后50～391天,还检测到抗JEV特异IgM抗体;7/16病人的CSF中,发病后30～251天,除检测到特异IgM抗体外,同时还检测到JEV抗原;3/1病人的CSF中,发病3周后分离到感染性病毒;其中1个病人发病后90、110和117天的CSF中连续分离到JEV;从CSF中分离到JEV的3例病人CSF均未查到抗JEV特异IgM抗体。
Of the 323 patients diagnosed with Japanese encephalitis, immunologic and virological evidence of the persistence of Japanese encephalitis virus (JEV) was found in the nervous system of 16 patients. In 9/16 patients with cerebrospinal fluid (CSF) 50 to 391 days after the onset of symptoms, anti-JEV-specific IgM antibodies were also detected; in CSF from 7/16 patients, 30 to 251 days after onset, except for specific IgM antibodies , And JEV antigens were detected at the same time; infectious virus was isolated in 3/1 patient CSF 3 weeks after onset; JEV was continuously isolated in CSF at 90, 110 and 117 days after onset in 1 patient; isolated from CSF None of the 3 patients with JEV had anti-JEV-specific IgM antibodies.