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[目的]观察六君子加减方对Okabe溃疡模型大鼠胃黏膜愈合及胃组织6-酮-前列腺素F1α(6-keto-PGF1α)的影响。[方法]采用Okabe乙酸烧灼法,在大鼠胃前壁造成溃疡,随机将模型动物分为模型,六君子大、中、小剂量,硫糖铝及法莫替丁组,分别连续给药治疗10 d。给药结束后,计算各组大鼠溃疡面积和溃疡指数,测定溃疡组织胃黏膜肌层缺损宽度及再生黏膜厚度,同时定量检测溃疡周围组织6-keto-PGF1α的水平。[结果]与模型组相比,所有给药组均能够降低黏膜肌层缺损宽度,提高再生黏膜厚度、胃组织6-keto-PGF1α的水平(均P<0.01);以六君子大剂量组作用更明显,与两西药组相比,差异有统计学意义(P<0.05)。[结论]六君子加减方能减小溃疡面积和溃疡指数,降低黏膜肌层缺损宽度,提高再生黏膜厚度,提高大鼠胃组织6-keto-PGF1α,提高溃疡大鼠胃黏膜愈合程度。
[Objective] To observe the effect of Six Gentian Jiajian Recipe on gastric mucosal healing and 6-keto-prostaglandin F1α (6-keto-PGF1α) in Okabe ulcer rat model. [Methods] Okabe acetic acid cauterization was used to induce ulcers in the anterior gastric wall of rats. The model animals were randomly divided into models, large, medium, and small doses of six gentlemen, sucralfate and famotidine groups. 10 d. After the administration, the ulcer area and ulcer index of each group were calculated. The width of mucosal musculature and the thickness of regenerative mucous membranes were determined. The level of 6-keto-PGF1α around the ulcer was also quantitatively measured. [Results]Compared with the model group, all administration groups were able to reduce the width of mucosal muscle defect, increase the thickness of regenerative mucosa and the level of 6-keto-PGF1α in gastric tissue (all P<0.01); More obvious, compared with the two western medicine group, the difference was statistically significant (P<0.05). [Conclusion] Six Gentian addition and subtraction can reduce the ulcer area and ulcer index, reduce the width of mucosal muscle defect, increase the thickness of regenerative mucosa, increase gastric tissue 6-keto-PGF1α, and increase the degree of gastric mucosal ulcer healing in rats.