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顺铂在临床上应用于多种肿瘤的治疗,也会引起广泛的不良反应如肾毒性、肝毒性、耳毒性等,限制了其临床应用,因此临床上主张联合用药以达到增效减毒的作用。本文概述了近些年来关于化学药及中药(中药成分、单味中药及中药复方)对顺铂的增效解毒作用方面的研究进展,为化疗药联合用药研究和临床给药方案的制定提供参考依据。
Cisplatin in clinical application of a variety of tumors, but also cause a wide range of adverse reactions such as nephrotoxicity, hepatotoxicity, ototoxicity, limiting its clinical application, it is clinically advocated that the combination of drugs in order to achieve synergistic attenuated effect. This article summarizes the research progress on synergistic detoxification of cisplatin with chemical drugs and traditional Chinese medicine (traditional Chinese medicine composition, single Chinese medicine and traditional Chinese medicine compound) in recent years, and provides references for the research of combination therapy of chemotherapeutic drugs and formulation of clinical dosage regimens. in accordance with.