应用重组人粒细胞集落刺激因子(rG—CSF),对39例接受大剂量化疗后粒细胞缺乏的急性白血病患者进行了治疗。结果发现在rG—CSF治疗后的3～11天,绝大多数患者白细胞回升、感染控制,除4例有骨痛、发热外,余未发现其它严重毒副作用。表明rG—CSF具有确切、快速、安全的升白细胞作用。本文对rG—CSF临床应用的有关问题进行了讨论。 Thirty-nine patients with acute leukemia who received agranulocytosis after high-dose chemotherapy were treated with recombinant human granulocyte-colony stimulating factor (rG-CSF). The results showed that in the 3 to 11 days after rG-CSF treatment, the majority of patients with leukocytosis, infection control, in addition to 4 cases of bone pain, fever, I found no other serious side effects. This indicates that rG-CSF has an exact, rapid and safe leukocyte-stimulating effect. This article discusses the clinical application of rG-CSF.