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目的 :研究低发病的中国汉族人群维生素D受体基因 (VDRG)BsmⅠ 位点单核苷酸多态性 (SNP)与前列腺癌的关系 ,探讨不同种族前列腺癌发病的基因差异。 方法 :收集中国北方地区汉族人群 10 3例前列腺癌病人及10 6例健康对照者外周血标本 ,应用变性高效液相色谱 (DHPLC)检测VDRG第 8内含子BsmⅠ多态位点 ,并对该位点SNP分布进行分析。 结果 :BsmⅠ 多态位点bb、Bb、BB基因型和等位基因在北方地区汉族前列腺癌病人及对照者中的分布频率差异无显著性 (P >0 .0 5 ) ,基因型分布频率分别为 92 .2 3%、7.77%、0和 94.34 %、5 .6 6 %、0 ;等位基因B、b分别为 3.88%、96 .12 %和 2 .91%、97.0 9%,而与高发病人群的分布相比有显著不同。 结论 :VDRGBsmⅠ多态性在低发病的中国汉族人群与前列腺癌无相关 ,其分布与高发病人群有明显差异 ,提示VDRGBsmⅠ多态性可能是前列腺癌发病种族差异的原因之一。
Objective: To investigate the relationship between single nucleotide polymorphism (SNP) at the Bsm Ⅰ site of vitamin D receptor gene (VDRG) and prostate cancer in Chinese Han population with low prevalence and to explore the genetic differences among different ethnic groups. Methods: Peripheral blood samples of 103 prostate cancer patients and 106 healthy controls were collected from northern Chinese Han population. The Bsm Ⅰ polymorphisms of the 8th intron of VDRG were detected by denaturing high performance liquid chromatography (DHPLC) Site SNP distribution analysis. Results: The frequencies of bb, Bb, BB genotypes and alleles in Bsm Ⅰ polymorphisms were not significantly different between Han patients with prostate cancer and controls in northern China (P> 0.05). The frequency of genotype distribution Were 92.23%, 7.77%, 0 and 94.34%, 5.66%, 0 respectively; the alleles B and B were 3.88%, 96.12% and 2.91%, 97.0% respectively, The distribution of high prevalence of the population is significantly different. Conclusion: VDRGBsm Ⅰ polymorphism has no correlation with prostate cancer in the low prevalence Han Chinese population. The distribution of VDRGBsm Ⅰ polymorphism is significantly different with that of the high incidence population. It suggests that VDRGBsm Ⅰ polymorphism may be one of the reasons for the racial differences in the incidence of prostate cancer.