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本文用免疫组化方法对52例乳腺良、恶性肿瘤组织中P53和bc1-2蛋白的表达状况进行了研究。发现p53和bc1-2蛋白在乳腺癌中的表达分别为54.35％和45.65％．而良性病变中均为阴性。p53的表达与乳腺癌的病理分级、癌细胞核分裂数的多少以及肿瘤淋巴结转移有明显关系。而bc1-2的表达则与上述指标无关。说明p53和bc1－2蛋白的过度表达在乳腺癌的发生和发展中起了重要作用。且p53蛋白可作为临床判断病情及病人预后的可靠指标。
In this paper, the expression of P53 and bcl-2 protein in 52 cases of breast benign and malignant tumors was studied by immunohistochemistry. The expression of p53 and bcl-2 protein in breast cancer was found to be 54.35% and 45.65%, respectively. All benign lesions were negative. The expression of p53 has a significant relationship with the pathological grade of breast cancer, the number of mitoses of cancer cells, and the lymph node metastasis of tumors. However, the expression of bc1-2 has nothing to do with the above indicators. It indicates that overexpression of p53 and bcl-2 plays an important role in the occurrence and development of breast cancer. And p53 protein can be used as a reliable indicator of clinical judgment of disease and prognosis of patients.