自1922年发现维生素D以来,曾认为它未经进一步代谢就直接作用于肠和骨的靶组织。然而,抗维生素D骨病的存在以及给维生素D后出现生物效应延缓,对这种概念提出了疑问。合成高比活性维生素D并采用新的层析法,可以清楚地证实该维生素的生物活性代谢物的存在。用新的层析系统结合质 Since vitamin D was discovered in 1922, it has been thought that it acts directly on intestinal and bone target tissues without further metabolism. However, the concept of anti-vitamin D bone disease and the delay in the biological effects of vitamin D raises questions about this concept. The synthesis of high specific activity vitamin D and the use of a new chromatographic method clearly demonstrate the presence of a biologically active metabolite of this vitamin. With the new chromatography system combination quality