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目的 :研究不同剂量金多靶对肥胖大鼠的减肥效果及机制。方法 :以单纯性肥胖大鼠的体重、Lee′s指数、腹腔脂肪细胞总量、脂肪细胞大小、脂肪细胞瘦素表达 (免疫组化 ,ABC法 )、血清瘦素 (放免法 )、血脂和血糖为指标 ,比较不同剂量金多靶灌服 1个月 (限制饮食 )的减肥效果。结果 :中等剂量 (每天4 0mg/ 10 0 g体重 )金多靶灌服 1个月后大鼠减肥疗效较好。减肥同时血胆固醇及血糖有不同程度降低。减肥有效时脂肪细胞瘦素表达减弱 ,血清瘦素水平明显升高。结论 :金多靶 (每天 4 0mg/ 10 0 g体重 )灌服 1个月对单纯性肥胖大鼠有明显减肥疗效。金多靶减肥疗效可能与提高血清瘦素水平有关。金多靶有降低血胆固醇的作用 ,肥胖合并高血糖时适当加大金多靶剂量有降血糖效果。
Objective: To study the effect and mechanism of different doses of gold multi-target on weight loss in obese rats. METHODS: Body weight, Lee’s index, total abdominal fat cells, adipocyte size, adipocyte leptin expression (immunohistochemistry, ABC method), serum leptin (immunocytochemistry), and serum lipids were measured in simple obese rats. Blood glucose is an indicator to compare the effects of different doses of gold multi-targeting for 1 month (restricted diet) on weight loss. Results : After a month of medium-dose (40 mg/100 g body weight per day) gold multi-target irrigation, the weight-loss effect of rats was better. At the same time, blood cholesterol and blood sugar have been reduced to varying degrees. When weight loss is effective, the expression of leptin in fat cells is weakened and serum leptin levels are significantly elevated. Conclusion: The gold multi-target (40 mg/100 g body weight per day) orally administered for 1 month has significant effect on weight loss in simple obesity rats. The efficacy of weight loss in multiple gold targets may be related to an increase in serum leptin levels. The gold multi-targets have the effect of lowering blood cholesterol. When obesity is combined with hyperglycemia, increasing the gold multi-target dose appropriately has a hypoglycemic effect.