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溴化异丙托品在临床上治疗血管运动性鼻炎有显效,又因其治愈率高,因而得以广泛应用,通过八个健康成人男性,采用放射受体分析(RRA)测量经鼻吸入后的血浆药浓度,并以唾液分泌量、心率和视觉调节力为客观指标,结合受试者的主观感觉,对溴化异丙托品的全身抗胆碱能作用进行了观察。试验采用双盲法,设给药组与安慰剂对照组,受试者每隔15分钟吸入40μg,共240μg,试验过程保持休息状态。结果表明,溴化异丙托品在体内很快
Ipratropium bromide is clinically effective in the treatment of vasomotor rhinitis and is widely used because of its high cure rate. Eight healthy adult males were tested for viability after nasal inhalation using radioimmunoassay (RRA) Plasma drug concentration, and to salivary secretion, heart rate and visual adjustment force as an objective indicator, combined with the subjective feeling of the subjects, the systemic anticholinergic effects of ipratropium bromide were observed. The trial used a double-blind trial of the drug-administered group versus the placebo-controlled group. Subjects ingested 40 μg every 15 minutes for a total of 240 μg, and the rest of the trial was maintained. The results show that ipratropium bromide in the body quickly