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为研究雌激素对卵巢摘除后已发生显著骨丢失的 balb/c系小鼠股骨骨折愈合的影响 ,将 144只 balb/c小鼠随机分为假手术组 (SO组 )、卵巢摘除组 (OVX组 )、补充低剂量雌激素组 (E1 组 )、补充高剂量雌激素组 (E2 组 )。小鼠于折骨后 5天、10天、15天、2 0天、30天处死 ,测定骨痂中的钙盐沉积率。结果 SO组、OVX组和 E1 组 ,骨痂中的钙盐沉积率在折骨后 15天达峰值 ,OVX组钙盐沉积峰值显著低于 SO组和 E1 组 (P<0 .0 5 ) ,后二者之间无显著差异。在 E2 组 ,骨痂中的钙盐沉积率峰值推迟至折骨后 2 0天方出现。表明卵巢摘除的的低雌激素状态和补充超生理剂量的雌激素均对小鼠骨折愈合不利 ,补充生理剂量的雌激素有利于去势后小鼠的骨折愈合
To investigate the effect of estrogen on the healing of femoral fracture in balb / c mice with significant loss of bone after ovariectomy, 144 balb / c mice were randomly divided into sham operation group (SO group), ovariectomized group (OVX Group), supplemented with low dose estrogen group (group E1) and high dose estrogen group (E2 group). The mice were sacrificed 5 days, 10 days, 15 days, 20 days and 30 days after the folding. The calcium deposition rate in the callus was measured. Results In SO group, OVX group and E1 group, the deposition rate of calcium in callus peaked at 15 days after fracture, the peak of calcium deposition in OVX group was significantly lower than that in SO group and E1 group (P <0.05) There was no significant difference between the two. In group E2, the peak calcium deposition rate in the callus was postponed until 20 days after the fracture. Both estrogen with low estrogen status and ovarian hypersensitive dose showed ovariectomization adversely affecting fracture healing in mice. Physiological dose of estrogen was beneficial to fracture healing in castrated mice