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目的探讨卵巢癌患者CA125检测联合彩色多普勒超声检查的意义。方法 2010年7月-2014年9月宁波大学医学院附属医院经术后病理诊断为卵巢上皮性癌患者86例作为研究对象,卵巢上皮性癌患者的超声检查情况,卵巢上皮性癌的病理分期及病理类型和血清CA125水平的关系,超声联合血清CA125检测对卵巢上皮性癌的诊断价值。结果 86例卵巢上皮性癌的超声图像结果显示:实性肿块、囊性肿块和混合型肿块分别为28例、18例和40例,分别占32.6%、20.9%和31.7%。卵巢上皮性癌的病理分期Ⅱ期的血清CA125水平和CA125阳性率较卵巢上皮性癌的病理分期Ⅰ期高(P<0.05),卵巢上皮性癌的病理分期Ⅲ期和Ⅳ期的血清CA125水平和CA125阳性率远远高于卵巢上皮性癌的病理分期Ⅰ期和Ⅱ期(P<0.05);卵巢透明细胞癌的血清CA125水平和CA125阳性率较卵巢黏液性腺癌高(P<0.05),卵巢浆液性腺癌、混合型腺癌和子宫内膜样腺癌的血清CA125水平和CA125阳性率高于卵巢透明细胞癌和卵巢黏液性腺癌(P<0.05)。血清CA125检测卵巢上皮性癌的阳性率为65.1%,超声检查卵巢上皮性癌的阳性率为74.4%,而超声联合血清CA125检测卵巢上皮性癌的阳性率为91.9%,明显高于CA125组和超声组(P<0.05)。结论超声和血清CA125对卵巢上皮性癌的诊断阳性率不高,超声联合CA125检测能够明显提高卵巢上皮性癌的检出率。
Objective To investigate the significance of CA125 combined with color Doppler ultrasonography in patients with ovarian cancer. Methods From July 2010 to September 2014, 86 cases of epithelial ovarian cancer were diagnosed by Affiliated Hospital of Ningbo University Medical College as the research object. The ultrasonography of epithelial ovarian cancer patients and the pathological stage of ovarian epithelial carcinoma And the relationship between pathological type and serum CA125 levels, the diagnostic value of ultrasound combined with serum CA125 in the diagnosis of epithelial ovarian cancer. Results The ultrasound images of 86 cases of epithelial ovarian cancer showed that the number of solid tumors, cystic tumors and mixed tumors were 28 cases, 18 cases and 40 cases, accounting for 32.6%, 20.9% and 31.7% respectively. The serum level of CA125 and the positive rate of CA125 in pathological stage Ⅱ of ovarian epithelial carcinoma were higher than those in stage Ⅰ of epithelial ovarian cancer (P <0.05), and the level of serum CA125 in stage Ⅲ and Ⅳ of ovarian epithelial carcinoma (P <0.05). The positive rate of CA125 and the positive rate of CA125 in ovarian clear cell carcinoma were higher than those in ovarian mucinous adenocarcinoma (P0.05) Serum CA125 levels and CA125 positive rates in ovarian serous adenocarcinoma, mixed adenocarcinoma and endometrioid adenocarcinoma were higher than those in clear cell ovarian carcinoma and ovarian mucinous adenocarcinoma (P <0.05). The positive rate of serum CA125 in detecting epithelial ovarian cancer was 65.1%, the positive rate of ultrasound in detecting epithelial ovarian cancer was 74.4%, while the positive rate of serum CA125 in detecting ovarian epithelial carcinoma was 91.9%, which was significantly higher than CA125 group and Ultrasound group (P <0.05). Conclusion The positive rate of ultrasound and serum CA125 in diagnosing ovarian epithelial carcinoma is not high. The combination of ultrasound and CA125 can obviously improve the detection rate of epithelial ovarian cancer.