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慢性间质性肾炎(XNH)类似无菌性非破坏性疾病,主要损害肾髓质,有硬化后果。作着探讨XNH的发病机制,检查没有慢性肾功能不全的XNH60例,平均年龄34.3±4.5岁,都进行全面检查,包括静脉尿路造影,核素肾显象和肾穿刺活检。用通常的方法测定血清IgA、IgG和IgM水平,用放射免疫法侧定IgE水平。分析病史,伴发病,用药史,过敏史和遗传性资料。检查以前10天停用的各种药物。对照组是15例健康人。研究结果 XNH的临床症状都很轻微,大多数是在预防性体检时偶然发现的,有些病例头痛,血压升高,全身无力。有中度蛋白尿(1g/24h),氮代谢指标正常。本组病例,60％尿比重
Chronic interstitial nephritis (XNH) resembles aseptic, non-destructive diseases that primarily damage the medulla and have a hardening effect. In order to investigate the pathogenesis of XNH, 60 cases of XNH without chronic renal insufficiency were examined, with an average age of 34.3 ± 4.5 years. All of them were undergone a comprehensive examination including intravenous urography, radionuclide imaging and renal biopsy. Serum IgA, IgG and IgM levels were measured by the usual methods and IgE levels were quantified by radioimmunoassay. Analysis of medical history, with the disease, medication history, history of allergy and hereditary data. Check out the previous 10 days to disable the various drugs. The control group was 15 healthy people. Findings The clinical symptoms of XNH were mild and most were found incidentally during preventive exams. Some cases had headaches, high blood pressure, and general weakness. A moderate proteinuria (1g / 24h), nitrogen metabolism indicators normal. This group of patients, 60% of urinary weight