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目的 研究单香菇多糖注射液与化疗合用对妊娠滋养细胞肿瘤（ＧＴＮ）的疗效和免疫指标的影响。方法 随机将３６例ＧＴＮ分成两组，分别为化疗组（Ａ）和化疗＋单香菇多糖组（Ｂ）各１８例，观察化疗疗效，毒副反应和外周血 Ｔ４／Ｔ８细胞比值和 ＮＫ细胞活性的变化。结果 两组临床特征，化疗疗效和 Ｔ４／Ｔ８比值差异无显著性（Ｐ＞０．０５），但Ｂ组治疗后ＮＫ细胞活性增高显著高于Ａ组（Ｐ＜０．０１），未观察到严重的毒副作用。结论 单香菇多糖注射液静脉注射 １ｍｇ，２次／周，可提高化疗期间ＧＴＮ的ＮＫ细胞活性，无严重毒副作用，其可作为ＧＴＮ的生物反应调节剂，安全应用于临床治疗。
Objective To study the effect of single lentinan polysaccharide injection combined with chemotherapy on the efficacy and immune parameters of gestational trophoblastic tumor (GTN). Methods Thirty-six cases of GTN were randomly divided into two groups: chemotherapy group (A) and chemotherapy + single lentinan group (B), 18 cases each. The efficacy of chemotherapy, toxicities, peripheral blood T4/T8 cell ratio and NK cell activity were observed. The change. Results There was no significant difference in clinical characteristics, chemotherapy efficacy and T4/T8 ratio between the two groups (P>0.05), but the activity of NK cells after treatment in group B was significantly higher than that in group A (P<0.01). Serious toxic side effects. Conclusion Single-injection polysaccharide injection of 1 mg intravenously twice a week can increase the activity of NK cells of GTN during chemotherapy, without serious side effects. It can be used as a biological response modifier of GTN, and it can be safely applied in clinical treatment.