阿霉素(adriamycin,ADM)是一种蒽环类抗肿瘤药,抗瘤谱广,但具有严重的心脏毒性,可引起致命的心律失常和心力衰竭。1,6-二磷酸果糖(fructose 1,6-diphosphate,FDP)是糖分解代谢的中间产物。补充外源性FDP不仅可作为高能底物,尚具有调节代谢、改善红细胞变形能力、稳定细胞膜和溶酶体膜等多种作用,临床上已用于治疗多种缺血性疾病。近来还发现FDP有与超氧化物岐化酶相同的功效,能抑制粒细胞氧自由基的产生。本文主要研究FDP对ADM心脏毒性的影响。 Adriamycin (ADM) is an anthracycline antineoplastic agent with a broad anti-tumor spectrum but severe cardiotoxicity that can cause fatal arrhythmias and heart failure. Fructose 1,6-diphosphate (FDP) is an intermediate of sugar catabolism. Exogenous FDP is not only used as a high-energy substrate, but also has a variety of roles in regulating metabolism, improving erythrocyte deformability, stabilizing cell membrane and lysosomal membrane, and has been clinically used to treat various ischemic diseases. Recently, FDP has also been found to have the same efficacy as superoxide dismutase, inhibiting the production of granulocyte-derived oxygen free radicals. This article focuses on FDP ADM cardiotoxicity.