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硝酸酯类的使用正在不断扩大.它们用于治疗慢性稳定的心绞痛、不稳定心绞痛、急性心肌梗塞并发症以及急性和慢性充血性心力衰竭的“非负荷”治疗.也可在外科手术时控制血液收缩压的升高.硝酸酯类的释放体系硝酸酯类的释放体系包括片剂、气雾剂、软膏、透皮贴膏、透粘膜片剂和静注剂型.硝酸异山梨醇的代谢物即5-硝酸异山梨醇作为抗心绞痛药物正在得到广泛的普及.硝酸甘油:硝酸甘油的给药方式和剂型很多.舌下和颊内给药起效快,但颊内给药持续时间长;气雾剂起效像舌下给药一样快;于胸、腹部、胳膊上部涂抹硝酸甘油软膏起效虽较慢,但作用持续时间长,非常适用于住院病人使用.透皮硝酸甘油贴膏是一种硝
The use of nitrates is expanding and they are used to treat chronic stable angina, unstable angina, acute myocardial infarction complications, and “non-load” treatment of acute and chronic congestive heart failure. Control of blood systolic blood pressure increased Nitrate release system Nitrate release system includes tablets, aerosols, ointments, transdermal patches, transmucosal tablets and intravenous formulations. Isosorbide dinitrate metabolism Isosorbide-5-nitrates are widely used as anti-anginal drugs, and nitroglycerin and nitroglycerin are administered in a large number of forms and forms, and sublingual and buccal administration have a rapid onset of action, but the duration of buccal administration is long ; Aerosol effect as fast as sublingual administration; in the chest, abdomen, upper arm coated with nitroglycerin ointment although the onset of slow, but the role of long duration, very suitable for inpatient use. Transdermal nitroglycerin paste Is a nitrate