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中国药典(1977)和许多国家药典~([1-5])对于葡萄糖酸钙(CaG)及其制剂的测定均采用EDTA络合滴定法,此法仅适用于测定不含其他钙盐或其他能和EDTA络合的阳离子的CaG样品。国内药厂生产的口服用CaG均残留一定量的草酸盐;在CaG注射液中通常添加少量乳酸钙(乳酸和氢氧化钙)作助溶剂。因此,药典法不能准确测定其中CaG的含
Chinese Pharmacopoeia (1977) and many national pharmacopoeia ~ ([1-5]) for the determination of calcium gluconate (CaG) and its preparation using EDTA complexometric titration, this method is only suitable for the determination of other calcium salts or other Cationic CaG samples that can complex with EDTA. Domestic pharmaceutical production of oral CaG residues are a certain amount of oxalate; in CaG injection usually add a small amount of calcium lactate (lactic acid and calcium hydroxide) as a cosolvent. Therefore, the pharmacopoeia method can not accurately measure the content of CaG