Ｗｉｓｔａｒ种大鼠口服板栗毛壳浸膏０．４５ｇ、０．９０ｇ与４．５ｇ／ｋｇ／日（即小、中与大剂量，分别相当于人临床用量的５倍、１０倍与５０倍）连续６个月，血象、血液生化检查、内脏器官肉眼观察及镜检与对照组相比较均无显著性差异。表明其毒性低，在临床常用剂量下服用板栗毛壳浸膏是安全的 Wistar rats were orally administered 0.45 g, 0.90 g and 4.5 g / kg / day of chestnut shell extract (ie, small, medium and large doses equivalent to 5, 10, and 50 times the human clinical dose, respectively) For 6 consecutive months, there was no significant difference in blood, blood biochemical examination, macroscopic observation of internal organs and microscopic examination compared with the control group. Indicating that its toxicity is low, it is safe to take chestnut shell extract at the clinically usual dose