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目的研究赤丹提取物(消炎、止痛中药复方制剂)对混合菌液所致大鼠慢性盆腔炎的作用。方法将大鼠单侧子宫内膜器械划伤,注入大肠杆菌与金黄色的葡萄球菌的混合菌液,制备大鼠慢性盆腔炎动物模型;造模20天后,给药20天,观察赤丹提取物对模型大鼠相关各项指标的影响。结果赤丹提取物可以抑制感染子宫肿胀率,降低血清TNF-α、IL-6水平;光镜下观察到,慢性盆腔炎病理改变也明显减轻。结论赤丹提取物对混合菌液所致大鼠慢性盆腔炎具有明显的治疗作用。
Objective To study the effect of Chidan extract (anti-inflammatory and analgesic traditional Chinese medicine compound preparation) on chronic pelvic inflammatory disease in rats induced by mixed broth. Methods Rat unilateral endometrium instruments were scratched and inoculated with E. coli and Staphylococcus aureus mixed broth to prepare animal models of chronic pelvic inflammatory disease in rats. Twenty days after the model was established, Chidan extract was observed for 20 days. Effects of various substances on various indexes of model rats. RESULTS Chidan extract could inhibit the rate of uterus swelling and reduce serum TNF-α and IL-6 levels. Observed under light microscope, the pathological changes of chronic pelvic inflammatory disease were also significantly reduced. Conclusion Chidan extract has obvious therapeutic effect on chronic pelvic inflammatory disease in rats induced by mixed bacteria solution.