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目的:观察多烯紫杉醇联合顺铂和5-氟尿嘧啶(DCF方案)诱导化疗对口腔黏膜鳞状细胞癌的近期疗效和不良反应。方法:51例患者均经病理组织学证实为口腔黏膜鳞癌,均接受1个疗程的DCF方案(多烯紫杉醇80mg/m2,顺铂80mg/m2,5-氟尿嘧啶750mg/m2×4d)化疗,并配合水化利尿、止吐及抗过敏等辅助治疗。平均21d后评定疗效,施行原发肿瘤局部扩大切除的联合根治术。化疗前详细记录病灶大小,采用WHO推荐评价实体肿瘤客观指标判定疗效,分为完全缓解、部分缓解及无效3级,总有效率为完全缓解+部分缓解病例。结果:近期疗效中,完全缓解12例,部分缓解27例,无效12例,总有效率(CR+PR)为76.47%(39/51)。未出现严重不良反应。结论:DCF方案对多数口腔颌面部鳞癌近期疗效明显,不良反应可以耐受,远期疗效尚待进一步研究证实。
Objective: To observe the short-term efficacy and side effects of docetaxel plus cisplatin and 5-fluorouracil (DCF) induction chemotherapy on oral squamous cell carcinoma. Methods: Totally 51 patients were confirmed by histopathology as oral mucosal squamous cell carcinoma. All patients received one course of DCF regimen (docetaxel 80mg / m2, cisplatin 80mg / m2 and 5-Fluorouracil 750mg / m2 × 4d) And with hydration diuretic, antiemetic and anti-allergy and other adjuvant therapy. After an average of 21d assessment of efficacy, the implementation of the primary tumor local excision combined with radical mastectomy. The size of the lesion was recorded in detail before chemotherapy, and the curative effect was evaluated according to the objective evaluation index of solid tumors recommended by WHO. The curative effect was divided into complete remission, partial remission and ineffective grade 3, and the total effective rate was complete remission + partial remission. Results: In the short term, complete remission was achieved in 12 cases, partial remission in 27 cases and ineffective in 12 cases. The total effective rate (CR + PR) was 76.47% (39/51). No serious adverse reactions occurred. Conclusion: The DCF regimen has obvious curative effect on the majority of oral and maxillofacial squamous cell carcinoma in recent time. The adverse reaction can be tolerated. The long-term curative effect remains to be confirmed.