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引言近年,由于采用了放射性配基结合受体、放射自显影、放射免疫和高压液相等技术,对阿片受体的分布、分离、纯化以及内源性阿片样肽的化学、功用等进行了一系列研究,使这一领域进展迅速。国内对阿片受体及内啡肽的研究概况已有几篇综述。本文拟对脑内阿片受体存在的部位、性质、构象、类型、提取和内啡肽的化学性质、构效关系及作用机理等研究近况作一介绍。
INTRODUCTION In recent years, the distribution, isolation and purification of opioid receptors and the chemistry and function of endogenous opioid peptides have been studied due to the use of radioligand binding receptors, autoradiography, radioimmunoassay and high pressure liquid phase techniques A series of studies have made rapid progress in this area. There are several reviews on the research status of opioid receptors and endorphins in China. This article intends to make an introduction on the present situation, such as the location, nature, conformation, type, extraction and the chemical properties of endorphin, structure-activity relationship and mechanism of opioid receptors in brain.