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目的建立眼氨肽注射液中砷、锑、铅、镉的测定方法。方法采用电感耦合等离子体质谱法(ICP-MS)对眼氨肽注射液中砷、锑、铅、镉进行同时测定。结果砷、锑、铅浓度在1~20 ng/ml,镉浓度在0.5~10 ng/ml范围内线型良好(铅r=1.000 0;砷r=0.999 9;镉r=0.999 6;锑r=0.999 5);平均回收率为砷100.28%,锑99.59%,铅99.02%,镉99.62%;精密度(RSD):铅为1.12%,砷为0.88%,镉为0.97%,锑为1.20%。结论该方法准确可靠,能够对4种元素进行同时测定,灵敏度高,重现性好。
Objective To establish a method for the determination of arsenic, antimony, lead and cadmium in eye aminopeptidase injection. Methods Inductively coupled plasma mass spectrometry (ICP-MS) was used to determine the contents of arsenic, antimony, lead and cadmium in the eye aminopeptidase injection simultaneously. Results The concentrations of arsenic, antimony and lead were in the range of 1 ~ 20 ng / ml and the concentrations of cadmium in the range of 0.5 ~ 10 ng / ml were good (Pb = 1.999 9; Cd = 0.999 9; Cd = 0.999 5). The average recoveries were 100.28% for arsenic, 99.59% for antimony, 99.02% for lead and 99.62% for cadmium. The RSDs were 1.12% for lead, 0.88% for arsenic, 0.97% for cadmium and 1.20% for antimony. Conclusion The method is accurate and reliable, and can simultaneously determine the four elements with high sensitivity and good reproducibility.