论文部分内容阅读
目的探讨头低位卧床模拟失重过程中肾素－血管紧张素－醛固酮系统的作用及使用套带的影响。方法１２名受试者，随机分为对照组和套带组各６人，进行了２１天－６°头低位卧床试验。对照组卧床中不用任何对抗措施，套带组卧床第１～１０天、１８～２１天每天８：３０～２０：３０四肢戴加压套带，压力维持在（４０±５）ｍｍＨｇ，第１１～１７天不使用套带。卧床前１天、卧床第３、７、１０、１３、１５、１９、２１天、卧床结束后第２、３天早餐前测体重；卧床前、卧床第２、４、１０、２１天清晨空腹取静脉血检测血浆肾素活性（ＰＲＡ）、醛固酮（ＡＬＤ）的变化。结果对照组卧床中体重减轻，其中第３天和第７天分别减轻４％和２．９％，达显著性差异；套带组卧床第１～１０天使用套带，体重无明显下降，撤套带后体重下降１．５％，再次使用套带，体重增加１．９％。两组卧床中血浆ＰＲＡ浓度升高，分别于第４天和第１０天达峰值（＋５４％、＋４６％），第２１天时恢复至卧床前水平。对照组卧床第２天血浆ＡＬＤ下降（－１５．５％），第４天回升（＋２５．５％），第１０天达峰值（＋４５．５％），卧床第２１天仍维持较高水平（＋３０％）；套带组卧床中ＡＬＤ变化基本相同，只是趋势延缓（－３３?
Objective To investigate the effect of renin-angiotensin-aldosterone system during head-weight-loss simulated bed-rest and the influence of using tape. Methods Twelve subjects were randomly divided into control group and lag band of 6, with 21 days -6 ° head-down bed test. In the control group, no countermeasures were taken in the bed of the control group. The banding group was placed on bed for 1 to 10 days and the skin pressure was maintained at (40 ± 5) mmHg from 8:30 to 20:30 every day for 18 to 21 days. ~ 17 days do not use the strap. 1 day before bedtime, 3,7,10,13,15,19,21 days in bed, and 2 days before bedtime after breakfast, the body weight was measured before breakfast; Before bedtime, bedside 2,4,10,21 days early morning fasting Venous blood was taken to measure the changes of plasma renin activity (PRA) and aldosterone (ALD). Results The body weight of the control group was reduced in bed, of which 4% and 2.9% on day 3 and day 7, respectively. There was a significant difference between the two groups. In the control group, After taking the weight loss of 1.5%, again using the tape, weight gain of 1.9%. Plasma PRA concentrations increased in both sets of bedridden subjects, reaching peak values (+54%, +46%) on day 4 and day 10, respectively, and returning to bedside levels on day 21. In control group, plasma ALD decreased (-15.5%), resumed on day 4 (+ 25.5%), peaked on day 10 (+ 45.5%) and remained high on day 21 + 30%). The change of ALD in bed-stratified group was basically the same, only the trend retardation (-33?