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异体骨髓移植后,输入的造血于细胞在受体植活,分化增殖以重建受体的造血功能是个复杂的过程.供体骨髓与受体免疫系统之间的相互排斥反应,可能产生、①稳定植活,②移植排斥,③供受体血细胞在受体共存的嵌合状态。识别移植后受体血细胞的来源,动态观察供受体血细胞数量的消长,是研究骨髓移植植活过程的一个重要课题。80年代之前,用于识别血细胞来源的标记有:①红细胞血型,②红细胞同功酶谱,③血清免疫球蛋白同种异型标记,④性染色体核型分析,⑤HLA 型等,大多数病例用上述方法可获得客观植活证明。但其应用各受一定的限制:前三项易受受体残留的
Allogeneic bone marrow transplantation, the input of hematopoietic cells in the recipient plantation, proliferation and proliferation to reconstitute the hematopoietic function of the recipient is a complex process. The donor bone marrow and receptor immune system between the mutual rejection may produce, stable Survival, ② transplant rejection, ③ for the recipient’s blood cells in the receptor co-existing chimerism. Recognition of the source of the recipient’s blood cells after transplantation and the dynamic observation of the increase and decrease of the number of donor’s blood cells are an important issue to study the process of bone marrow transplantation. Prior to the 1980s, markers used to identify the origin of blood cells were: ① erythrocyte blood group, ② erythrocyte zymogram, ③ serum immunoglobulin allotype marker, ④ sex chromosome karyotype analysis, ⑤ HLA type, etc. In most cases, Methods to obtain objective evidence of plant survival. However, its application is subject to certain restrictions: the first three vulnerable receptors