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目的探讨肾黏液管状梭形细胞癌(MTSCC)的临床病理学特征、诊断及鉴别诊断。方法对7例MTSCC进行临床病理学观察及免疫组化标记,并复习相关文献。结果7例中5例为女性,发病年龄34～80岁,平均49.1岁,多为体检发现。镜检示,肿瘤黏液性基质中大部分为嗜酸性胞质的立方形细胞,呈紧密排列的小管状或乳头状结构,部分为束状排列的梭形细胞,可见成簇的泡沫细胞和慢性炎症细胞浸润。免疫组化示7例CK、CK7、CK19、vimentin和AMACR均(+),6例CK8和34βE12(+),5例CD15、4例CHG和3例RCC(+)。结论MTSCC是低度恶性的肾肿瘤,有其独特的病理形态特征,预后良好。
Objective To investigate the clinicopathological characteristics, diagnosis and differential diagnosis of renal mucinous tubular spindle cell carcinoma (MTSCC). Methods Seven cases of MTSCC were observed by clinicopathology and immunohistochemistry, and the related literatures were reviewed. Results Of the 7 cases, 5 were female and their age of onset was 34 to 80 years (average 49.1 years). Most of them were physical examinations. Microscopically, the majority of tumor mucinous matrix was eosinophilic cytoplasm cubic cells, arranged closely tubular or papillary structure, part of the bundle-like spindle cells, showing clusters of foam cells and chronic Inflammatory cell infiltration. Immunohistochemistry showed CK, CK7, CK19, vimentin and AMACR in all 7 cases, 6 cases of CK8 and 34βE12 (+), 5 cases of CD15, 4 cases of CHG and 3 cases of RCC (+). Conclusion MTSCC is a low-grade renal tumor with its unique pathological features and good prognosis.