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缺氧缺血性脑病(Hypoxic-Ischemic Encephalopathy,HIE)是指各种围生期窒息引起的缺氧、脑血流减少或暂停而导致胎儿或新生儿脑损伤,是引起婴幼儿神经心理发育障碍的主要疾病之一。发达国家足月活产儿HIE发病率为3/1 000～5/1 000,其中,中重度HIE发病率约1/1 000～2/1 000。国内报道HIE发病率因地区不同略有差异,但明显高于国外,达3%～10%。即使在发达国家的转诊中心,中重度HIE患儿仍有53%～61%发生中重度残疾或死亡。近年来的研究显示,促红细胞生成素(Erythropoietin,EPO)除促红细胞生成作用外,还具有介导缺氧缺血后神经保护的功能。现对EPO对HIE的神经保护作用研究进展进行综述。
Hypoxic-ischemic encephalopathy (HIE) refers to various perinatal asphyxia caused by hypoxia, cerebral blood flow reduction or suspension caused by fetal or neonatal brain injury, is caused by neurological disorders in infants and young children development One of the major diseases. The incidence of HIE in full-term live births in developed countries is 3/1 000 ~ 5/1 000, of which the incidence of moderate to severe HIE is about 1/1 000 ~ 2/1 000. Domestic reports of HIE incidence varies slightly by region, but significantly higher than abroad, up 3% to 10%. Even in referral centers in developed countries, moderate to severe disability or death occurs in 53% to 61% of children with moderate-to-severe HIE. In recent years, studies have shown that erythropoietin (EPO) in addition to the role of erythropoiesis, but also has a neuroprotective effect after hypoxic-ischemic. EPO on HIE neuroprotective effects are reviewed.