目的研究大叶钩藤(Uncaria macrophylla Wall.)根的化学成分。方法用甲醇提取及柱色谱等方法进行分离,波谱法鉴定结构。结果从大叶钩藤根部位中分离并鉴定了6个化合物,其结构分别为钩藤碱(1)、异钩藤碱(2)、乌苏酸(3)、β-谷甾醇(4)、taraxerol(5)、myricadoil(6)。结论首次报道大叶钩藤根的化学成分;实验结果可为大叶钩藤的进一步研究开发提供科学依据。 Objective To study the chemical constituents of Uncaria macrophylla Wall. The method was separated by methanol extraction and column chromatography, and the structure was identified by spectroscopy. Results Six compounds were isolated and identified from the roots of Uncaria macrophylla. The structures of them were as follows: rhynchophylline (1), isorhamnetin (2), ursolic acid (3), β-sitosterol taraxerol (5), myricadoil (6). Conclusion The chemical composition of root of Uncaria macrophylla was reported for the first time. The experimental results could provide a scientific basis for further research and development of Uncaria macrophylla.