目的：研究海风藤对人类神经母细胞瘤细胞系列淀粉样前体蛋白（βＡＰＰ）基因表达的抑制作用。方法：应用Ｎｏｒｔｈｅｒｎ印迹杂交观察βＡＰＰｍＲＮＡ的变化，应用细胞存活率、乳酸脱氢酶（ＬＤＨ）释放、细胞集落观察海风藤对神经细胞的直接作用。结果：海风藤选择性的抑制βＡＰＰ基因表达。实验浓度内未发现细胞毒性作用。结论：βＡＰＰ与Ａｌｚｈｅｉｍｅｒ’ｓ病（ＡＤ）的发病关系密切，海风藤选择性抑制βＡＰＰ基因表达为其防治ＡＤ提供了一定的依据 OBJECTIVE: To study the inhibition of amyloid precursor protein (βAPP) gene expression in human neuroblastoma cells by Kadurabium. METHODS: Northern blot hybridization was used to observe the change of β-APP mRNA. The cell viability, release of lactate dehydrogenase (LDH), and cell colony were used to observe the direct effect of seaweed on nerve cells. RESULTS: Kadsura selectively inhibited the expression of β-APP gene. No cytotoxic effect was found within the experimental concentration. Conclusion: β-APP is closely related to the incidence of Alzheimer’s disease (AD), and the selective inhibition of βAPP gene expression by seaweed provides a certain basis for the prevention and treatment of AD.