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目的 探索迷走神经刺激控制癫痫的最佳刺激参数 .方法 在青霉素诱发的癫痫模型上 ,电刺激迷走神经以控制大鼠的癫痫发作 ,比较不同频率和不同时间序列电脉冲的迷走神经刺激对大鼠癫痫的抑制作用 .结果 迷走神经刺激可以抑制青霉素诱发的大鼠癫痫活动 .在 5～ 2 0Hz范围内 ,随迷走神经刺激频率的增高 ,迷走神经刺激对大鼠癫痫的抑制程度从 (6 8 3± 10 2 ) %增大到 (97 1± 19 5 ) % ,对癫痫的抑制时间从 (5 1 7± 2 5 )s增加到 (45 1 5± 4 8 2 )s (P <0 0 1) .不同时间序列的迷走神经刺激对大鼠癫痫的抑制作用是不同的 ,混沌的迷走神经刺激比周期的迷走神经刺激对癫痫的抑制程度大 ,分别是 (88 3± 2 8) %和 (72 4± 3 6 ) % ,(P <0 0 5 ) ,抑制时间也长 ,分别为 (2 4 3 3± 2 1 5 )s和 (15 3 4± 17 2 )s,(P <0 0 5 ) .结论 刺激电脉冲的时间序列是影响迷走神经刺激效果的重要参数之一 ,混沌的迷走神经刺激对大鼠癫痫的抑制作用比周期的迷走神经刺激的作用强 .
Objective To explore the optimal stimulation parameters of vagal nerve stimulation to control epilepsy.Methods In the penicillin-induced epilepsy model, the vagus nerve is electrically stimulated to control the seizure in rats, and the inhibition of epilepsy by vagus nerve stimulation of different frequency and time series electric pulse .Results Vagus nerve stimulation can inhibit penicillin-induced seizure activity in rats.Under the range of 5 ~ 20 Hz, vagus nerve stimulation reduced the degree of epilepsy induced by vagus nerve stimulation from (6 8 3 ± 10 2)% (97 1 ± 19 5)%, and the inhibition time of epilepsy increased from (51 7 ± 2 5) s to (45 1 5 ± 4 8 2) s (P 0 01) Vagus nerve stimulation had different inhibitory effects on epilepsy in rats. Chaos vagal stimulation suppressed the epilepsy more than vagus nerve stimulation (88 3 ± 2 8%) and (72 4 ± 3 6%), respectively P <0.05), and the inhibitory time was longer (2 433 ± 2 1 5) s and (15 3 4 ± 17 2) s, respectively (P 0 05) Sequence is an important parameter affecting vagal nerve stimulation effect Strong chaos vagus nerve stimulation on inhibitory effect of vagus nerve stimulation in rats with epilepsy than fans cycles role.