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目的通过对照研究观察阿霉素神经干注射治疗带状疱疹后神经痛的临床疗效。方法60例带状疱疹后神经痛患者,根据不同治疗方法随机分为4组:A组:阿霉素神经干注射+射频热凝术+常规治疗;B组:阿霉素神经干注射+常规治疗;C组:射频热凝术+常规治疗;D组:常规治疗(对照组)。在治疗前、治疗后1、3、6个月和1年时进行VAS评分。结果A组的显效率和有效率最高, 但与B组之间并无统计学差异。B组治疗的显效率要高于C组(P<0.05)。A、B、C 3组和D组间的疗效有统计学差异(P<0.05)。A、B组治疗前后的VAS评分存在统计学差异(P<0.01),并且随时间的推移, VAS评分逐渐减小,没有患者出现复发。而C组虽然治疗前后的VAS评分差异有统计学意义(P<0.01), 但随时间的推移,VAS评分逐渐增加,部分患者疼痛复发。1年后的随访VAS评分时,A、B组和C组之间出现统计学差异(P<0.05)。结论阿霉素神经干注射治疗带状疱后神经痛具有较好的治疗效果,并且远期疗效好,复发率低。
Objective To observe the clinical efficacy of doxorubicin-induced neuralgia in the treatment of post-herpetic neuralgia through a controlled study. Methods Sixty patients with postherpetic neuralgia were randomly divided into 4 groups according to different treatment methods: group A: injection of adriamycin by neural stem plus radiofrequency thermocoagulation plus conventional therapy; group B: injection of adriamycin by neural stem plus conventional C group: radiofrequency thermocoagulation + routine treatment; D group: conventional treatment (control group). VAS scores were assessed before treatment, 1, 3, 6 months and 1 year after treatment. Results A group of markedly efficient and efficient, but with no significant difference between the B group. The effective rate of B group was higher than that of C group (P <0.05). A, B, C group and the efficacy of D group was statistically significant (P <0.05). There was a significant difference in VAS scores between A and B groups before and after treatment (P <0.01), and with the passage of time, the VAS score gradually decreased and no patients relapsed. However, the VAS scores of group C before and after treatment were significantly different (P <0.01). However, the VAS score gradually increased over time, and some patients recurred. There was a significant difference (P <0.05) between A, B group and C group after one year follow-up VAS score. Conclusion Injection of doxorubicin into neural stem cells has good curative effect in the treatment of BPH, and long-term curative effect and low recurrence rate.