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目的:观察黄芪注射液联合盐酸拉贝洛尔注射液治疗妊娠高血压综合征(PIH)的临床疗效,及其对患者肾功能和妊娠结局的影响。方法:按随机数字表法将78例PIH患者分为对照组和研究组各39例。对照组给予盐酸拉贝洛尔注射液治疗,研究组在对照组用药基础上加用黄芪注射液。比较2组临床疗效,观察2组治疗前后肾功能指标的变化,记录2组妊娠结局。结果:研究组总有效率94.87%,对照组79.49%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组α1-微球蛋白(α1-MG)、尿素氮(BUN)、尿肌酐(UCr)及尿酸(UA)水平均较治疗前降低(P<0.01),研究组α1-MG、BUN、UCr及UA水平均低于对照组(P<0.01)。治疗后研究组胎心异常发生率和新生儿窒息发生率均低于对照组(P<0.05)。结论:黄芪注射液联合盐酸拉贝洛尔注射液治疗PIH,能提高患者的临床疗效,改善肾功能和妊娠结局。
Objective: To observe the clinical efficacy of Astragalus injection combined with labetalol injection in treating pregnancy induced hypertension (PIH) and its effect on renal function and pregnancy outcome. Methods: According to the random number table, 78 patients with PIH were divided into control group and study group, 39 cases each. The control group was treated with labetalol injection, and the study group was given astragalus injection on the basis of the control group. The clinical curative effect was compared between the two groups. The change of renal function index in two groups before and after treatment was observed. The pregnancy outcome was recorded in two groups. Results: The total effective rate was 94.87% in the study group and 79.49% in the control group. There was significant difference between the two groups (P <0.05). After treatment, the levels of α1-MG, BUN, UCr and UA in the two groups were lower than those before treatment (P <0.01). The levels of α1-MG, BUN, UCr and UA levels were lower than the control group (P <0.01). After treatment, the incidence of abnormal fetal heart rate and neonatal asphyxia in the study group were lower than those in the control group (P <0.05). Conclusion: Astragalus injection combined with labetalol injection in the treatment of PIH can improve the clinical efficacy of patients, improve renal function and pregnancy outcome.