The westerly winds and East Asian summer monsoon play a leading role in climate change of southwestern North America and eastern Asia since the Last Glacial Maximum(LGM),respectively.Their convergence in arid and semi-arid regions of the Asian continent(AAC) makes the regional climate change more complicated on the millennial-scale.There are still limitations in applying paleoclimate records and climate simulations of characteristic periods to investigate climate change patterns since the LGM in this region.In this study,we adopt two indexes indicating effective moisture and rely on a continuous simulation,a time slice simulation,and numerous paleoclimate records to comprehensively investigate the cli-mate change modes and their driving mechanisms since the LGM in AAC.Results demon-strate a millennial-scale climate differentiation phenomenon and three climate change modes possibly occurring in AAC since the LGM.The western AAC largely controlled by the westerly winds is featured as wet climates during the LGM but relatively dry climates during the mid-Holocene (MH),coinciding with the climate change mode in southwestern North America.Conversely,dry conditions during the LGM and relatively wet conditions during the MH are reflected in eastern AAC governed by the East Asian summer monsoon,which leans to the climate change mode in eastern Asia.If climate change in central AAC is forced by the in-teraction of two circulations,it expresses wet conditions in both the LGM and MH,tending to a combination of the southwestern North American and eastern Asian modes.Precipitation and evaporation exert different intensities in influencing three climate modes of different periods.Furthermore,we identify the significant driving effects of greenhouse gases and ice sheets on westerly-dominated zones of AAC,while orbit-driven insolation on monsoon-dominated zones of AAC.