论文部分内容阅读
目的 探讨NMDA受体系统在外周体表致炎局部和远隔部位痛感受差异反应中的作用。方法 雌性Wistar大鼠 141只 ,随机分为 6组。压脚法测双后足痛阈值 (mmHg)。前 3组先一侧后肢足底致炎 ,然后腹腔分别给NMDA受体拮抗剂CGP37849(5mg·kg-1)、激动剂NMDA(5mg·kg-1)和生理盐水 (1ml)。后 3组先腹腔分别给上述试剂 ,然后致炎。分别观察各组、各时刻双后足痛阈变化。结果 前 3组致炎后 ,致炎足痛阈降低 (P <0 0 5 ) ,非致炎足痛阈升高 (P <0 0 5 )。腹腔给CGP37849、NMDA后 ,致炎足分别表现为痛阈的回升和进一步下降 (P <0 0 5 )。非致炎足痛阈分别表现为痛阈进一步增高和降低 (P <0 0 5 )。后 3组致炎后 ,致炎足痛阈分别表现为轻度下降、明显下降 (P <0 0 5 )和降低 (P <0 0 5 )。非致炎足痛阈分别表现为轻度增高、下降 (P <0 0 5 )和增高。结论 NMDA受体系统与致炎局部和远隔部位痛感受的差异反应有关 即NMDA受体激动剂有助于致炎局部痛敏的发生和发展 ,减弱远隔部位的抗伤害性反应 ;NMDA受体拮抗剂则减弱致炎局部的痛敏程度 ,增强远隔部位的抗伤害性反应
OBJECTIVE: To investigate the role of NMDA receptor system in the differential response to pain in local and remote parts of the peripheral body. Methods 141 female Wistar rats were randomly divided into 6 groups. Prescription foot test double hind pain threshold (mmHg). The first three groups were exposed to inflammation of the hindlimb plantar first, then the NMDA receptor antagonist CGP37849 (5 mg · kg -1), NMDA agonist NMDA (5 mg · kg -1) and saline (1 ml) were intraperitoneally injected respectively. After the first three groups were given the above intraperitoneal agents, and then cause inflammation. The changes of double hind paw pain thresholds in each group were observed. Results After the first three groups were inflammation, the pain threshold of inflammatory pain decreased (P <0 05) and the threshold of non-inflammatory pain increased (P 0 05). After intraperitoneal injection of CGP37849 and NMDA, the pain threshold increased and further decreased (P <0.05). Non-inflammatory foot pain threshold were shown as further increased and decreased pain threshold (P <0 05). After inflammation in the latter three groups, the pain threshold of inflammatory pain showed a slight decrease, a significant decrease (P <0 05) and a decrease (P 0 05) respectively. Non-inflammatory foot pain threshold showed mild increase, decreased (P <0 05) and increased. Conclusion The NMDA receptor system is related to the difference in pain perception between the local and remote parts of the inflammation. NMDA receptor agonists contribute to the occurrence and development of local inflammatory hyperalgesia and attenuate the anti-nociceptive responses at distant sites. NMDA receptor Body antagonists reduce the degree of hyperalgesia pain sensitivity and enhance the anti-nociceptive response