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目的探讨耐“异烟肼、利福平”肺结核患者采用6/卷曲霉素(卡那霉素)、吡嗪酰胺、丙硫异烟胺、对氨基水杨酸、左氧氟沙星/18吡嗪酰胺、丙硫异烟胺、对氨基水杨酸、左氧氟沙星方案的临床效果及影响因素。方法2010年1年邯郸市传染病医院对第七轮中国全球基金耐多药结核项目符合入组条件的31例患者采用上述方案治疗24个月。治疗过程中定期检查患者肝功能、肾功能、血常规、尿常规、痰涂片找结核菌、胸部X线片。结果 31例患者中男性21例、女性10例,患者年龄23~70岁。完成治疗后痰菌阴转率54.8%,病变明显吸收35.48%,抗结核药物不良反应发生率54.84%。治疗结果显示:31例患者治愈率为54.84%,结核患者的年龄、病史长短对耐“异烟肼、利福平”结核病的治疗成败差异均有统计学意义(χ2=2.544,P<0.05;χ2=6.903,P<0.05)。结论年龄、肺结核病史长短对耐多药结核患者治疗成败有影响。本方案治疗耐“异烟肼、利福平”肺结核效果满意,但费用较高,可用于临床治疗耐多药肺结核患者。
Objective To investigate the effects of 6 / capreomycin (kanamycin), pyrazinamide, propylthiouracil, p-aminosalicylic acid, levofloxacin / 18 pyrazine Amide, propylthiouracil, p-aminosalicylic acid, levofloxacin clinical efficacy and influencing factors. Methods In 2010, 31 patients in Handan Infectious Disease Hospital who were eligible for inclusion in the seventh round of China Global Fund multidrug-resistant tuberculosis project were treated with the above protocol for 24 months. During the treatment of patients regularly check liver function, renal function, blood, urine, tuberculosis sputum smear, chest X-ray. Results Among the 31 patients, 21 were males and 10 were females. The patients were 23 to 70 years old. After completion of treatment sputum negative conversion rate of 54.8%, lesions significantly absorbed 35.48%, anti-TB drug adverse reaction rate of 54.84%. The treatment results showed that the cure rate of 31 patients was 54.84%. The age of patients with tuberculosis and the length of their history had statistically significant differences between the two groups in the treatment success or failure of resistance to isoniazid and rifampicin (χ2 = 2.544, P < 0.05; χ2 = 6.903, P <0.05). Conclusions Age and the history of tuberculosis have an impact on the success or failure of MDR-TB treatment. The treatment of this program resistant to “isoniazid, rifampicin” satisfactory results of tuberculosis, but the higher the cost, can be used for clinical treatment of multi-drug resistant tuberculosis patients.